The Preventive Cardiovascular Nurses Association believes that all nurses should integrate the recently updated 2018 American College of Cardiology (ACC)/American Heart Association (AHA)/multi-society cholesterol guideline and the U.S. Department of Health and Human Services’ physical activity guidelines into their clinical practice and personal lifestyle. Given nurses’ education and expertise, they are well positioned to address both primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD)—the major cause of death and disability worldwide.